Potential selective advantage mechanism for polymorphic genetics in celiac disease.

Celiac Disease is a common cause of morbidity in the developed world but its etiology is still unknown. Considering that Celiac Disease was first documented in Scandinavian Europe, a population exposed to a high fat diet, perhaps the polymorphic genetics of the disease provides balanced polymorphism against this environmental stimulus. Celiac Disease has been associated with higher levels of the T cell receptor (TCR)γδ, receptors that have played a greater role in recognizing microbial lipids. Furthermore, obesity has been associated with lower levels of CD-3 expression while Celiac Disease has been associated with an up regulation of this molecule. These finding might help to describe a balance polymorphism that exists in Celiac Disease as well as an etiological factor that lead to the development of the disease.