Department of Pathology, Touro College of Osteopathic Medicine, 230 West 125th Street, New York, NY 10027, USA.
Med Hypotheses. 2011 Jul;77(1):3-4. doi: 10.1016/j.mehy.2011.04.029. Epub 2011 May 14.
Celiac Disease is a common cause of morbidity in the developed world but its etiology is still unknown. Considering that Celiac Disease was first documented in Scandinavian Europe, a population exposed to a high fat diet, perhaps the polymorphic genetics of the disease provides balanced polymorphism against this environmental stimulus. Celiac Disease has been associated with higher levels of the T cell receptor (TCR)γδ, receptors that have played a greater role in recognizing microbial lipids. Furthermore, obesity has been associated with lower levels of CD-3 expression while Celiac Disease has been associated with an up regulation of this molecule. These finding might help to describe a balance polymorphism that exists in Celiac Disease as well as an etiological factor that lead to the development of the disease.
乳糜泻是发达国家常见的发病率原因，但病因仍不清楚。鉴于乳糜泻最初是在斯堪的纳维亚欧洲（北欧）记录的，那里的人们摄入高脂肪饮食，也许这种疾病的多态性遗传为这种环境刺激提供了平衡的多态性。乳糜泻与较高水平的 T 细胞受体（TCR）γδ相关，这些受体在识别微生物脂质方面发挥了更大的作用。此外，肥胖与 CD-3 表达水平降低有关，而乳糜泻与这种分子的上调有关。这些发现可能有助于描述乳糜泻中存在的平衡多态性，以及导致疾病发展的病因因素。
