Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, Utrecht, The Netherlands.
Curr Opin Cell Biol. 2011 Aug;23(4):498-504. doi: 10.1016/j.ceb.2011.04.005. Epub 2011 May 14.
Most proteins follow the classical secretory pathway from the endoplasmic reticulum, via the Golgi, to the plasma membrane or extracellular medium. However, some proteins reach these final destinations by two alternative routes. One sustains the extracellular delivery of cytoplasmic proteins that lack a signal peptide, the other supports the transport of transmembrane proteins to the plasma membrane in a manner that bypasses the Golgi. Here, we highlight the observation that some unconventional secretion events are triggered by cellular stress. Furthermore, one Golgi protein, Golgi Re-Assembly and Stacking Protein (GRASP), has been shown to be essential to both types of unconventional secretion and we discuss ways in which it may support these events in a Golgi-independent manner.
大多数蛋白质遵循经典的分泌途径，从内质网经过高尔基体，到达质膜或细胞外介质。然而，一些蛋白质通过两种替代途径到达这些最终目的地。一种途径维持缺乏信号肽的细胞质蛋白质的细胞外递呈，另一种途径以绕过高尔基体的方式将跨膜蛋白运输到质膜。在这里，我们强调了这样一个观察结果，即一些非常规的分泌事件是由细胞应激触发的。此外，一种高尔基体蛋白，高尔基体重组和堆积蛋白（GRASP），已被证明对这两种非常规分泌途径都是必不可少的，我们讨论了它如何以高尔基体非依赖性的方式支持这些事件的方式。
