Bernhard E J
Radiotherapy Development Branch, Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute/National Institutes of Health, 6130 Executive Boulevard, Rockville, MD 20892-7440, United States.
Cancer Radiother. 2011 Aug;15(5):376-82. doi: 10.1016/j.canrad.2011.01.007. Epub 2011 May 14.
Non-surgical cancer therapeutic strategies have focused primarily on direct killing of cancer cells by chemotherapy and/or radiation therapy. However, it is becoming increasingly clear that the efficacy of these therapies can be significantly influenced by the tumor microenvironment. The microenvironment poses both obstacles and opportunities for new therapeutic interventions. New developments in this area are the topic of this review.
非手术癌症治疗策略主要集中在通过化疗和/或放射疗法直接杀死癌细胞。然而，越来越明显的是，这些疗法的疗效会受到肿瘤微环境的显著影响。微环境对新的治疗干预既构成障碍，也带来机遇。该领域的新进展是本综述的主题。
