Department of Pediatrics, University Medical Center Groningen, University of Groningen, The Netherlands.
Arterioscler Thromb Vasc Biol. 2011 Aug;31(8):1726-33. doi: 10.1161/ATVBAHA.108.181206. Epub 2011 May 12.
Reverse cholesterol transport (RCT) is usually defined as high-density lipoprotein-mediated transport of excess cholesterol from peripheral tissues, including cholesterol-laden macrophages in vessel walls, to the liver. From the liver, cholesterol can then be removed from the body via secretion into the bile for eventual disposal via the feces. According to this paradigm, high plasma high-density lipoprotein levels accelerate RCT and hence are atheroprotective. New insights in individual steps of the RCT pathway, in part derived from innovative mouse models, indicate that the classical concept of RCT may require modification.
胆固醇逆向转运（RCT）通常被定义为高密度脂蛋白介导的外周组织中胆固醇的转运，包括血管壁中载脂巨噬细胞的胆固醇，至肝脏。从肝脏中，胆固醇可以通过分泌到胆汁中，最终通过粪便排出体外。根据这一模式，高血浆高密度脂蛋白水平加速了 RCT，因此具有抗动脉粥样硬化作用。RCT 途径中各个步骤的新见解，部分源自创新的小鼠模型，表明 RCT 的经典概念可能需要修正。
