Simula Research Laboratory, Centre for Biomedical Computing, PO Box 134, Lysaker 1325, Norway.
J R Soc Interface. 2011 Aug 7;8(61):1212-6. doi: 10.1098/rsif.2011.0152. Epub 2011 May 13.
The well-organized contraction of each heartbeat is enabled by an electrical wave traversing and exciting the myocardium in a regular manner. Perturbations to this wave, referred to as arrhythmias, can lead to lethal fibrillation if not treated within minutes. One manner in which arrhythmias originate is an ill-fated interaction of the regular electrical signal controlling the heartbeat, the sinus wave, with an ectopic stimulus. It is not fully understood how and when ectopic waves are generated. Based on mathematical models, we show that ectopic beats can be characterized in terms of unstable eigenmodes of the resting state.
有规律的电脉冲波穿过并以规则的方式刺激心肌，从而使每次心跳都能有序收缩。如果不对这种电脉冲波（即心律失常）加以干预，它可能在数分钟内引发致命的纤维性颤动。心律失常的一个成因是，控制心跳的窦性电信号与异位刺激之间不幸相互作用。目前人们并不完全了解异位波是如何以及何时产生的。基于数学模型，我们发现可以用静息状态下不稳定的本征模式来描述异位搏动。
