Peters Katherine B, Cummings Thomas J, Gururangan Sridharan
Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
J Pediatr Hematol Oncol. 2011 Jul;33(5):e198-201. doi: 10.1097/MPH.0b013e318205e230.
Patients with juvenile pilocytic astrocytoma (JPA) and neurofibromatosis type I (NF-1) tend to have a more indolent course than those with sporadic tumors. In rare circumstances, transformation to anaplastic pilocytic astrocytoma (APA) has been known to occur in sporadic cases and is associated with exposure to ionizing radiation. We present 2 patients with NF-1 who were initially diagnosed with JPA that later transformed to APA. Both patients were not exposed to ionizing radiation but instead received alkylator chemotherapy before transformation. Possibility of conversion to APA should be considered in patients with NF-1 and JPA who have rapid tumor recurrence.
患有青少年毛细胞型星形细胞瘤（JPA）和I型神经纤维瘤病（NF-1）的患者往往比散发性肿瘤患者病程更为惰性。在罕见情况下，散发性病例中已知会发生向间变性毛细胞型星形细胞瘤（APA）的转变，且与电离辐射暴露有关。我们报告了2例NF-1患者，他们最初被诊断为JPA，后来转变为APA。两名患者均未暴露于电离辐射，而是在转变前接受了烷化剂化疗。对于NF-1和JPA且肿瘤快速复发的患者，应考虑转变为APA的可能性。
