Gustafsson Britt, Hellebostad Marit, Ifversen Marianne, Sander Birgitta, Hasle Henrik
Astrid Lindgren Children's Hospital, Huddinge, Karolinska University Hospital-Huddinge, Sweden.
J Pediatr Hematol Oncol. 2011 Dec;33(8):e363-7. doi: 10.1097/MPH.0b013e3182055e44.
Juvenile myelomonocytic leukemia is a rare hematopoietic stem cell disease in children with features of both myelodysplasia and myeloproliferation. Extramedullary involvement has been reported and pulmonary involvement secondary to leukemic infiltration is an initial manifestation, which may result in acute respiratory failure.
We present 3 children with juvenile myelomonocytic leukemia and suspected pulmonary leukemic cell infiltration who all also suffered from respiratory insufficiency. The differential diagnosis included asthma and infections.
In each case the patients improved rapidly after initiation of antileukemic treatment including 6-mercaptopurine or cytarabine.
青少年粒单核细胞白血病是一种罕见的儿童造血干细胞疾病，具有骨髓发育异常和骨髓增殖的特征。已有髓外受累的报道，白血病浸润继发的肺部受累是首发表现，可导致急性呼吸衰竭。
我们报告3例青少年粒单核细胞白血病且疑似肺部白血病细胞浸润的患儿，他们均患有呼吸功能不全。鉴别诊断包括哮喘和感染。
在每例患者中，开始使用包括6-巯基嘌呤或阿糖胞苷在内的抗白血病治疗后，病情迅速改善。
