Rossi Francesca Flavia, Pedone Claudio, Antonelli Incalzi Raffaele
Università Campus Biomedico Area di geriatria Via Alvaro del Portillo 21 00128 Roma.
Recenti Prog Med. 2011 Mar;102(3):109-13. doi: 10.1701/608.7066.
Chronic obstructive pulmonary disease (COPD) is the only chronic disease whose prevalence is increasing. It is the third cause of death wordwide, and it is projected to became the third in about ten years. COPD is strongly associated with cardiovascular diseases: this association is in part explained by risk factors in common (especially smoking), but in the latest years the hypothesis that COPD may cause a systemic inflammatory state, that in turn causes the increased risk of cardiovascular diseases in these patients, is taking over. The aim of this paper is to review the available evidence about the association of COPD with systemic inflammation, and how this is linked with development of cardiovascular diseases.
慢性阻塞性肺疾病（COPD）是唯一一种患病率正在上升的慢性疾病。它是全球第三大致死原因，预计在大约十年内将成为第三大死因。COPD与心血管疾病密切相关：这种关联部分是由共同的危险因素（尤其是吸烟）解释的，但近年来，COPD可能导致全身炎症状态，进而导致这些患者心血管疾病风险增加的假说正在占据主导地位。本文的目的是综述关于COPD与全身炎症关联的现有证据，以及这与心血管疾病发展的联系。
