Mecker Laura C, Filla Laura A, Martin R Scott
Saint Louis University, Department of Chemistry, 3501 Laclede Avenue, St. Louis, MO 63103.
Electroanalysis. 2010 Oct 1;22(19):2141-2146. doi: 10.1002/elan.201000118.
In this communication, we demonstrate that a carbon ink microelectrode array, where the electrodes are held at the same potential, affords significant signal enhancement in microchip electrophoresis with amperometric detection. The ability to fabricate an array of carbon ink microelectrodes with a palladium decoupler was demonstrated and the resulting electrodes were integrated with a valving microchip design. The use of an 8 electrode array led to a significant improvement in the limits of detection at the expense of separation resolution due to the increased detection zone size. It is also shown that microdialysis sampling can be integrated with the microchip device and a multi-analyte separation achieved.
在本通讯中，我们证明了一种碳墨微电极阵列，其中电极保持在相同电位，在采用安培检测的微芯片电泳中能实现显著的信号增强。展示了制造带有钯解耦器的碳墨微电极阵列的能力，并将所得电极与阀控微芯片设计集成。使用8电极阵列导致检测限显著改善，但由于检测区尺寸增加，分离分辨率有所牺牲。还表明微透析采样可与微芯片装置集成，并实现多分析物分离。
