Liu Aiping, Nickerson Andrew, Troyer Aaron, Yin Xin, Cary Robert, Thornburg Kent, Wang Ruikang, Rugonyi Sandra
Division of Biomedical Engineering, Oregon Health & Science University, Portland, OR, 97239, USA.
Comput Struct. 2011 Jun 1;89(11-12):855-867. doi: 10.1016/j.compstruc.2011.03.003.
Wall shear stresses (WSS) exerted by blood flow on cardiac tissues modulate growth and development of the heart. To study the role of hemodynamic conditions on cardiac morphogenesis, here, we present a methodology that combines imaging and finite element modeling to quantify the in vivo blood flow dynamics and WSS in the cardiac outflow tract (OFT) of early chicken embryos (day 3 out of 21-day incubation period). We found a distinct blood flow field and heterogeneous distribution of WSS in the chicken embryonic heart OFT, which have physiological implications for OFT morphogenesis.
血流施加在心脏组织上的壁面剪应力（WSS）调节心脏的生长和发育。为了研究血流动力学条件在心脏形态发生中的作用，在此，我们提出一种方法，该方法结合成像和有限元建模来量化早期鸡胚（21天孵化期的第3天）心脏流出道（OFT）中的体内血流动力学和WSS。我们在鸡胚心脏OFT中发现了独特的血流场和WSS的异质分布，这对OFT形态发生具有生理学意义。
