Center for Biofluid and Biomimic Research, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, South Korea.
Microvasc Res. 2011 Nov;82(3):296-303. doi: 10.1016/j.mvr.2011.09.005. Epub 2011 Sep 21.
Cardiac outflow in the early developmental stage of a chick embryo is known to be highly variable depending on environmental temperature. To investigate the effects of environmental hypothermia on the blood flow in the outflow tract (OFT) of chick embryonic hearts, microscopic flow images were consecutively captured from chick embryos at HH stage 17 (2.5 days of incubation) at room temperature. Instantaneous velocity field information of blood flow in OFT was obtained using a micro-particle image velocimetry technique. The cyclic variations of the OFT vessel diameter and wall thickness were simultaneously measured. The experimental results show that environmental hypothermia causes bradycardia with a decrease in peak velocity during systole and the occurrence of backflow during diastole in the OFT. These abnormal phenomena seem to be attributed to the suppression of myocardial wall motion under hypothermic conditions.
鸡胚心脏发育早期的流出道血流受环境温度影响较大。为了研究环境低温对鸡胚心脏流出道血流的影响，本研究在室温下对孵化 2.5 天（HH17 期）的鸡胚进行了连续的微观血流成像。利用微粒子图像测速技术获得了血流在流出道中的瞬时速度场信息。同时测量了流出道血管直径和壁厚的周期性变化。实验结果表明，环境低温导致心动过缓，收缩期峰值速度降低，舒张期出现反流。这些异常现象似乎归因于低温条件下心肌壁运动的抑制。
