黑素细胞-角质形成细胞移植治疗色素脱失痣。
Nevus depigmentosus treated by melanocyte-keratinocyte transplantation.
作者信息
Mulekar Sanjeev V, Al Issa Ahmed, Al Eisa Abdullah
机构信息
National Center for Vitiligo and Psoriasis, Olaya District, Tahlia Street, Riyadh, Kingdom of Saudi Arabia.
出版信息
J Cutan Aesthet Surg. 2011 Jan;4(1):29-32. doi: 10.4103/0974-2077.79185.
BACKGROUND
Nevus depigmentosus is a congenital, nonprogressive hypopigmented disorder. Various therapeutic methods have been attempted to repigment nevus with variable results.
OBJECTIVE
The objective of this study is to report our experience of treatment of nevus depigmentosus with a combination of noncultured melanocyte-keratinocyte transplantation (MKTP) and excimer laser sessions.
MATERIALS AND METHODS
Six patients (male 1, female 5) of nevus depigmentosus were treated with a combination of noncultured melanocyte-keratinocyte transplantation and excimer laser. One patient was lost to follow-up. Remaining five patients were observed for a period ranging from 7 to 30 months.
RESULTS
Two patients responded poorly to MKTP. The remaining three patients responded with repigmentation ranging from 80% to 100% but the quality of repigmentation was unsatisfactory in two of them.
CONCLUSION
Though repigmentation of nevus depigmentosus is possible by grafting techniques, the results are inconsistent and recurrence is possible.
背景
色素脱失痣是一种先天性、非进行性色素减退性疾病。人们尝试了各种治疗方法来使色素脱失痣重新着色，结果各不相同。
目的
本研究的目的是报告我们采用非培养黑素细胞-角质形成细胞移植（MKTP）联合准分子激光治疗色素脱失痣的经验。
材料与方法
6例色素脱失痣患者（男1例，女5例）接受了非培养黑素细胞-角质形成细胞移植联合准分子激光治疗。1例患者失访。其余5例患者观察7至30个月。
结果
2例患者对MKTP反应不佳。其余3例患者色素重新沉着率为80%至100%，但其中2例色素重新沉着的质量不理想。
结论
虽然通过移植技术使色素脱失痣重新着色是可能的，但结果并不一致，且可能复发。
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