可降解酪氨酸衍生聚碳酸酯生物材料及其共混物的薄膜弹性模量
Thin Film Elastic Modulus of Degradable Tyrosine-Derived Polycarbonate Biomaterials and Their Blends.
作者信息
Aamer Khaled A, Stafford Christopher M, Richter Lee J, Kohn Joachim, Becker Matthew L
机构信息
Polymers Division, National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg, Maryland 20899-854.
出版信息
Macromolecules. 2009 Jan 22;42(4):1212-1218. doi: 10.1021/ma802115b.
The integrity, function, and performance of biomedical devices having thin polymeric coatings are critically dependent on the mechanical properties of the film, including the elastic modulus. In this report, the elastic moduli of several tyrosine-derived polycarbonate thin films, specifically desaminotyrosyl ethyl tyrosine polycarbonates p(DTE carbonate), an iodinated derivative p(I(2)-DTE carbonate), and several discrete blends are measured using a method based on surface wrinkling. The data shows that the elastic modulus does not vary significantly with the blend composition as the weight percentage of p(I(2)-DTE carbonate) increases for films of uniform thickness in the range of 67 to 200 nm. As a function of film thickness, the observed elastic moduli of p(DTE carbonate), p(I(2)-DTE carbonate) and their 50:50 by mass blend show little variation over the range 30 to 200 nm.
具有薄聚合物涂层的生物医学设备的完整性、功能和性能严重依赖于薄膜的机械性能，包括弹性模量。在本报告中，使用基于表面起皱的方法测量了几种酪氨酸衍生的聚碳酸酯薄膜的弹性模量，具体为脱氨基酪氨酸乙酯酪氨酸聚碳酸酯p（DTE碳酸盐）、一种碘化衍生物p（I(2)-DTE碳酸盐）以及几种离散共混物。数据表明，对于厚度在67至200纳米范围内的均匀厚度薄膜，随着p（I(2)-DTE碳酸盐）重量百分比的增加，弹性模量不会随共混物组成而显著变化。作为薄膜厚度的函数，p（DTE碳酸盐）、p（I(2)-DTE碳酸盐）及其质量比为50:50的共混物在30至200纳米范围内观察到的弹性模量变化很小。
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