Prommer Eric, Thompson Lisa
Division of Hematology/Oncology, Mayo Clinic College of Medicine, Mayo Clinic Hospital, Scottsdale, AZ, USA.
Patient Prefer Adherence. 2011 Mar 18;5:157-64. doi: 10.2147/PPA.S7665.
Of several newer delivery systems under development and investigation for the administration of opioids, the intranasal route has received a substantial amount of attention. Intranasal administration is a convenient form of delivery that is applicable to several opioids. It has the potential for self-administration, combined with a rapid onset of action, allowing for patient-controlled analgesia. In clinical practice, intranasal administration has been found to be a reliable drug delivery method that is familiar to patients. Intranasal opioids have proven to be useful in both in-hospital and out-of-hospital pain management settings. Fentanyl, a highly lipophilic step 3 opioid, has been evaluated for intranasal administration. The purpose of this review is to examine the role of the nasal route of opioid administration and examine the evidence base for the use of fentanyl intranasally.
在正在研发和研究的几种用于阿片类药物给药的新型给药系统中，鼻内给药途径受到了大量关注。鼻内给药是一种方便的给药方式，适用于多种阿片类药物。它具有自我给药的潜力，起效迅速，可实现患者自控镇痛。在临床实践中，鼻内给药已被证明是一种患者熟悉的可靠给药方法。鼻内阿片类药物已被证明在院内和院外疼痛管理环境中均有用处。芬太尼是一种高度亲脂性的Ⅲ级阿片类药物，已对其鼻内给药进行了评估。本综述的目的是探讨阿片类药物鼻内给药途径的作用，并审视鼻内使用芬太尼的证据基础。
