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青光眼小梁切除术中结膜下应用丝裂霉素C与结膜下应用5-氟尿嘧啶的疗效比较：一项随机临床试验

Augmenting trabeculectomy in glaucoma with subconjunctival mitomycin C versus subconjunctival 5-fluorouracil: a randomized clinical trial.

作者信息

Mostafaei Ali

机构信息

Nikoukari Ophthalmology University Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.

出版信息

Clin Ophthalmol. 2011;5:491-4. doi: 10.2147/OPTH.S17328. Epub 2011 Apr 18.

DOI:10.2147/OPTH.S17328
PMID:21573097
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3090304/
Abstract

OBJECTIVE

The aim of this study was to compare the efficacy of augmenting trabeculectomy with subconjunctival mitomycin C (TMMC) versus 5-fluorouracil (T5-FU) in lowering intraocular pressure (IOP).

METHODS

Forty eyes from 40 patients referred to the Nikoukari Ophthalmology University Hospital, Tabriz University of Medical Sciences, Tabriz, Iran, were enrolled in a randomized clinical trial. Patients with high-risk open angle glaucoma were allocated to receive either subconjunctival TMMC or T5-FU.

RESULTS

Mean overall preoperative IOP was 30.8 mmHg. Mean preoperative IOPs in the TMMC and T5-FU groups were 31.2 ± 9.8 and 30.6 ± 9.9 mmHg, respectively. Postoperatively, mean IOPs were 11.4.3 ± 4.9 and 13.6 ± 3.9 mmHg, respectively for TMMC and T5-FU groups after 6 months. In spite of some existing descriptive differences in IOP between the groups, statistical tests showed no difference in mean and median IOP. Three cases of hypotonia (IOP < 6 mmHg) and 1 case of epithelial keratitis were detected.

CONCLUSION

TMMC and T5-FU appeared to have similar efficacy in lowering IOP.

摘要

目的

本研究旨在比较小梁切除术联合结膜下丝裂霉素C（TMMC）与5-氟尿嘧啶（T5-FU）降低眼压（IOP）的疗效。

方法

40例患者的40只眼睛被纳入一项随机临床试验，这些患者来自伊朗大不里士医科大学大不里士尼库卡里眼科大学医院。高危开角型青光眼患者被分配接受结膜下TMMC或T5-FU治疗。

结果

术前平均眼压为30.8 mmHg。TMMC组和T5-FU组术前平均眼压分别为31.2±9.8 mmHg和30.6±9.9 mmHg。术后6个月，TMMC组和T5-FU组的平均眼压分别为11.4±4.9 mmHg和13.6±3.9 mmHg。尽管两组间眼压存在一些现有的描述性差异，但统计检验显示平均眼压和中位数眼压无差异。检测到3例低眼压（IOP<6 mmHg）和1例上皮性角膜炎。

结论

TMMC和T5-FU在降低眼压方面似乎具有相似的疗效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4b/3090304/67f63916c279/opth-5-491f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4b/3090304/7babc8f37dab/opth-5-491f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4b/3090304/c929465f1851/opth-5-491f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4b/3090304/67f63916c279/opth-5-491f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4b/3090304/7babc8f37dab/opth-5-491f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4b/3090304/c929465f1851/opth-5-491f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4b/3090304/67f63916c279/opth-5-491f3.jpg

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