Kawana T
Dept. of Obstetrics and Gynecology, Tokyo University Branch Hospital.
Gan To Kagaku Ryoho. 1990 Apr;17(4 Pt 1):615-9.
From epidemiological viewpoint, it has been elucidated that cervical cancer is caused by something transmitted through sexual contact. At present, human papilloma virus, HPV, is thought to be one of the most important candidates, because 60-80% of invasive cancer as well as 30-50% of premalignant lesions of the cervix contain HPV, most of which is HPV-16 or 18. However, these HPVs are detected in the cervices of normal women, suggesting that it is mandatory to clarify the natural history of these HPVs to know the role played by these in the carcinogenesis.
从流行病学的观点来看，已经明确宫颈癌是由通过性接触传播的某种因素引起的。目前，人乳头瘤病毒（HPV）被认为是最重要的候选因素之一，因为60%-80%的浸润性宫颈癌以及30%-50%的宫颈癌前病变中都含有HPV，其中大多数是HPV-16或HPV-18。然而，在正常女性的宫颈中也能检测到这些HPV，这表明有必要弄清楚这些HPV的自然史，以便了解它们在致癌过程中所起的作用。
