Tsuchiya H, Tomita K, Yasutake H, Morishita H, Morikawa S, Ono M, Tsuchida T, Takagi Y
Dept. of Orthopedic Surgery, School of Medicine, Kanazawa University.
Gan To Kagaku Ryoho. 1990 Apr;17(4 Pt 1):681-4.
We treated a 43-year-old man with recurrent malignant fibrous histiocytoma in right distal femur with intra-arterial infusion of cisplatin and caffeine 5 years after wide excision and chemotherapy. At the time of the first recurrence in the lateral aspect of thigh, intra-arterial infusion of CDDP (120 mg/m2) was ineffective. We treated him with radiation (7000 rad), and there was no evidence of tumor by radiological evaluation. The second local recurrence was treated with intra-arterial infusion of CDDP (120 mg/m2/1 hour) and caffeine (1.2 g/m2/24 hours x 3 days), and the tumor disappeared, radiologically and histologically. Caffeine did not increase the nephrotoxicity of CDDP, and no insomnia nor palpitation was seen. Intra-arterial infusion of CDDP and caffeine could be useful to increase the effect of CDDP for regional chemotherapy.
我们对一名43岁男性患者进行了治疗，该患者右股骨远端复发性恶性纤维组织细胞瘤，在广泛切除和化疗5年后接受了顺铂和咖啡因的动脉内灌注治疗。在大腿外侧首次复发时，动脉内灌注顺铂（120mg/m²）无效。我们对他进行了放射治疗（7000拉德），放射学评估未发现肿瘤迹象。第二次局部复发采用动脉内灌注顺铂（120mg/m²/1小时）和咖啡因（1.2g/m²/24小时×3天）进行治疗，肿瘤在放射学和组织学上均消失。咖啡因未增加顺铂的肾毒性，也未出现失眠或心悸。动脉内灌注顺铂和咖啡因可能有助于增强顺铂在区域化疗中的效果。
