Kuritsuka H, Narahara R, Sigeta M, Kobayashi Y, Kondo M, Fujita M, Ohno K, Kushima K
1st Department of Internal Medicine, Kyoto Prefectural University of Medicine.
Nihon Gan Chiryo Gakkai Shi. 1990 Nov 20;25(11):2711-6.
Primary mediastinal malignant germinoma is a rare disease, and only about 15 patients have been reported in Japan. We treated a patient with this disease by intra-arterial CDDP infusion and observed good effects. A 29 year-old male was admitted to our hospital due to SVC syndrome in 1980. A right mediastinal tumor was detected, and the resection of this tumor was performed. Histological examination showed seminoma. Though postoperative Co irradiation was performed, radiation pneumonitis developed in the right lung. Subsequently, the tumor metastasized to the right kidney and spinal cord. After removal of the right kidney followed by Co irradiation, the clinical course was good. In 1987, a mass (10 x 6 cm) was detected in the left mediastinum, suggesting recurrence. Four courses of CDDP infusion into the left bronchial artery and left internal thoracic artery (1 course: 45-70 mg) were performed, and good effects were obtained. No side effects were observed, and the clinical course has been good until now. This case is of interest in evaluating the multidisciplinary treatment for mediastinal seminoma.
原发性纵隔恶性生殖细胞瘤是一种罕见疾病，在日本仅有约15例患者报道。我们通过动脉内顺铂灌注治疗了一名患有该疾病的患者，并观察到良好效果。一名29岁男性于1980年因上腔静脉综合征入住我院。检测到右纵隔肿瘤，并对该肿瘤进行了切除。组织学检查显示为精原细胞瘤。尽管术后进行了钴放疗，但右肺发生了放射性肺炎。随后，肿瘤转移至右肾和脊髓。在切除右肾并进行钴放疗后，临床过程良好。1987年，在左纵隔检测到一个肿块（10×6厘米），提示复发。对左支气管动脉和左胸廓内动脉进行了四个疗程的顺铂灌注（1个疗程：45 - 70毫克），并取得了良好效果。未观察到副作用，至今临床过程良好。该病例对于评估纵隔精原细胞瘤的多学科治疗具有重要意义。
