Endocrine and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Biol Trace Elem Res. 2011 Dec;144(1-3):217-24. doi: 10.1007/s12011-011-9074-1. Epub 2011 May 15.
Nutritional deficiencies are important and widespread problems in most developing countries. Preventing and correcting micronutrient deficiencies are important because of the multiple negative consequences of these deficiencies. This study was designed to determine the prevalence of copper deficiency in an adult population in Shiraz, southern Iran. We also determined the association between copper status and other factors such as age, sex, and body mass index (BMI). In this cross-sectional study, 416 adults residing in Shiraz were selected by two-stage sampling. Serum copper was measured by flame-atomic absorption spectrometry. The data were analyzed with SPSS software. Mean age in our sample was 39.33 ± 15.06 years, and mean BMI was 26.17 ± 4.81 kg/m(2). Mean serum copper concentration was 118.15 ± 54.33 μg/dL in the whole sample, 109.74 ± 56.22 μg/dL in men, and 122.15 ± 53.04 μg/dL in women. The overall prevalence of copper deficiency was 24%. The prevalence of copper deficiency differed significantly between men and women but not between different age groups. Serum copper concentration correlated significantly with BMI (p < 0.05). This study is the first to evaluate serum copper status in a healthy population in southern Iran. We show that the mean copper concentrations were higher than those reported for Iranian populations in northern cities and were also higher compared with studies in most other countries. We suggested more detailed studies to identify the etiological determinants of this nutritional deficiency in Iran and elsewhere.
营养缺乏是大多数发展中国家普遍存在的重要问题。预防和纠正微量营养素缺乏非常重要，因为这些缺乏会带来多种负面影响。本研究旨在确定伊朗南部设拉子市成年人群中铜缺乏的流行情况。我们还确定了铜状况与其他因素（如年龄、性别和体重指数（BMI））之间的关联。在这项横断面研究中，通过两阶段抽样选择了 416 名居住在设拉子的成年人。通过火焰原子吸收光谱法测量血清铜。使用 SPSS 软件分析数据。我们样本的平均年龄为 39.33±15.06 岁，平均 BMI 为 26.17±4.81kg/m2。在整个样本中，平均血清铜浓度为 118.15±54.33μg/dL，男性为 109.74±56.22μg/dL，女性为 122.15±53.04μg/dL。铜缺乏的总体患病率为 24%。男性和女性之间的铜缺乏患病率存在显著差异，但不同年龄组之间无差异。血清铜浓度与 BMI 呈显著相关（p<0.05）。本研究首次评估了伊朗南部健康人群的血清铜状况。我们发现，平均铜浓度高于伊朗北部城市报告的浓度，也高于大多数其他国家的研究报告的浓度。我们建议进行更详细的研究，以确定伊朗和其他地区这种营养缺乏的病因决定因素。
