Mazariegos L A, Lukert P D, Brown J
Department of Medical Microbiology, College of Veterinary Medicine, University of Georgia, Athens 30602.
Avian Dis. 1990 Jan-Mar;34(1):203-8.
This study was conducted to test the pathogenicity and immunosuppressive effects of seven commercially available infectious bursal disease (IBD) vaccines. These vaccine strains are intermediate in their pathogenicity in susceptible specific-pathogen-free (SPF) chickens. One-day-old and 3-week-old SPF chickens were vaccinated with these vaccines. Two weeks after IBD vaccination, they were vaccinated with Newcastle disease virus (NDV). The pathogenic and immunosuppressive effects of the IBD vaccines were evaluated by the antibody response to NDV vaccination, the bursa: body weight index, and histopathological lesions of the bursa. It was found that these strains were highly variable in their virulence and immunosuppressive properties. Three of the strains tested were found to be highly virulent and immunosuppressive; two others were moderate; and two could be classified as mild.
本研究旨在测试七种市售传染性法氏囊病（IBD）疫苗的致病性和免疫抑制作用。这些疫苗毒株对易感的无特定病原体（SPF）鸡的致病性处于中等水平。1日龄和3周龄的SPF鸡接种了这些疫苗。在接种IBD疫苗两周后，它们接种了新城疫病毒（NDV）。通过对NDV疫苗接种的抗体反应、法氏囊：体重指数以及法氏囊的组织病理学损伤来评估IBD疫苗的致病性和免疫抑制作用。结果发现，这些毒株在毒力和免疫抑制特性方面差异很大。所测试的毒株中有三种被发现具有高毒力和免疫抑制性；另外两种为中等毒力；还有两种可归类为低毒力。
