Institute for Anatomy and Cell Biology, Department of Molecular Embryology, Albert Ludwigs University Freiburg, Albertstrasse 17, 79104 Freiburg, Germany.
Cell Tissue Res. 2012 Jan;347(1):65-72. doi: 10.1007/s00441-011-1186-6. Epub 2011 May 17.
Klf10 and Klf11 belong to the family of Sp1/Krüppel-like zinc finger transcription factors that play important roles in a variety of cell types and tissues. Although Klf10 and Klf11 were initially introduced as transforming growth factor-beta (TGF-beta)-inducible genes, several studies have described their upregulation by a plethora of growth factors, cytokines and hormones. Here, we review the current knowledge of the inductive cues for Klf10 and Klf11 and focus on their transcriptional regulation by members of the TGF-beta superfamily. We further summarize their involvement in the regulation of the TGF-beta signaling pathway and discuss their possible role as molecules mediating crosstalk between various signaling pathways. Finally, we provide an overview of the pro-apoptotic and anti-proliferative functions of Klf10 and Klf11.
Klf10 和 Klf11 属于 Sp1/Krüppel 样锌指转录因子家族，它们在多种细胞类型和组织中发挥着重要作用。尽管 Klf10 和 Klf11 最初被介绍为转化生长因子-β（TGF-β）诱导基因，但有几项研究描述了它们被多种生长因子、细胞因子和激素上调。在这里，我们回顾了 Klf10 和 Klf11 的诱导线索的最新知识，并重点介绍了它们在 TGF-β 超家族成员中的转录调控。我们进一步总结了它们在 TGF-β 信号通路调节中的作用，并讨论了它们作为介导各种信号通路之间串扰的分子的可能作用。最后，我们概述了 Klf10 和 Klf11 的促凋亡和抗增殖功能。
