Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Marchioninistr. 15, 81377 Munich, Germany.
Department of Gynecology and Obstetrics, University Hospital Augsburg, Stenglinstraße 2, 86156 Augsburg, Germany.
Int J Mol Sci. 2020 Apr 22;21(8):2928. doi: 10.3390/ijms21082928.
KLF11 (Krüppel-like factor 11) belongs to the family of Sp1/Krüppel-like zinc finger transcription factors that play important roles in a variety of cell types and tissues. KLF11 was initially described as a transforming growth factor-beta (TGF-β) inducible immediate early gene (TIEG). KLF11 promotes the effects of TGF-β on cell growth control by influencing the TGFβ-Smads signaling pathway and regulating the transcription of genes that induce either apoptosis or cell cycle arrest. In carcinogenesis, KLF11 can show diverse effects. Its function as a tumor suppressor gene can be suppressed by phosphorylation of its binding domains via oncogenic pathways. However, KLF 11 can itself also show tumor-promoting effects and seems to have a crucial role in the epithelial-mesenchymal transition process. Here, we review the current knowledge about the function of KLF11 in cell growth regulation. We focus on its transcriptional regulatory function and its influence on the TGF-β signaling pathway. We further discuss its possible role in mediating crosstalk between various signaling pathways in normal cell growth and in carcinogenesis.
KLF11（Krüppel 样因子 11）属于 Sp1/Krüppel 样锌指转录因子家族，在多种细胞类型和组织中发挥重要作用。KLF11 最初被描述为转化生长因子-β（TGF-β）诱导的即刻早期基因（TIEG）。KLF11 通过影响 TGFβ-Smads 信号通路和调节诱导细胞凋亡或细胞周期停滞的基因转录，促进 TGF-β 对细胞生长的控制作用。在癌症发生过程中，KLF11 可以表现出多种作用。其作为肿瘤抑制基因的功能可以通过癌基因途径对其结合域的磷酸化来抑制。然而，KLF11 本身也可以表现出促进肿瘤的作用，并且似乎在上皮-间充质转化过程中具有关键作用。本文综述了 KLF11 在细胞生长调控中的功能的最新知识。我们重点讨论了其转录调节功能及其对 TGF-β 信号通路的影响。我们进一步讨论了其在介导正常细胞生长和癌症发生过程中各种信号通路之间的串扰中的可能作用。
