Wągrowska-Danilewicz Małgorzata, Danilewicz Marian
Department of Nephropathology, Medical University of Łódź.
Pol J Pathol. 2011;62(1):12-8.
The glomerular lesion of paraneoplastic nephrotic syndrome usually presents as membranous nephropathy, minimal change disease or membranoproliferative glomerulonephritis. We present six cases of paraneoplastic nephrotic syndrome. Four cases were associated with epithelial malignancies (lung, gastric and colon cancer), and two cases with lymphoproliferative malignancies (Hodgkin's lymphoma and chronic lymphocytic leukemia). On the basis of light microscopy, immunofluorescence study and electron microscopy, membranous nephropathy, minimal change disease, and membranoproliferative glomerulopathy were established. We concluded, that the search for malignancy is warranted in patients over the age of 55 presenting with nephrotic syndrome, particularly in cases of membranous nephropathy.
副肿瘤性肾病综合征的肾小球病变通常表现为膜性肾病、微小病变肾病或膜增生性肾小球肾炎。我们报告6例副肿瘤性肾病综合征。4例与上皮性恶性肿瘤（肺癌、胃癌和结肠癌）相关，2例与淋巴增殖性恶性肿瘤（霍奇金淋巴瘤和慢性淋巴细胞白血病）相关。基于光镜、免疫荧光研究和电子显微镜检查，确诊为膜性肾病、微小病变肾病和膜增生性肾小球病。我们得出结论，对于55岁以上出现肾病综合征的患者，尤其是膜性肾病患者，有必要进行恶性肿瘤筛查。
