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迈向对二氢吡啶敏感钙通道的理解。

Toward an understanding of the dihydropyridine-sensitive calcium channel.

作者信息

McKenna E, Koch W J, Slish D F, Schwartz A

机构信息

Department of Pharmacology and Cell Biophysics, University of Cincinnati Medical Center, OH 45267-0575.

出版信息

Biochem Pharmacol. 1990 Apr 1;39(7):1145-50. doi: 10.1016/0006-2952(90)90255-j.

Abstract

The dihydropyridine-sensitive calcium channel continues to fascinate scientific investigators. Each new discovery leads to more complexity. Further work elucidating the molecular structures and functions of the various isoforms of the channel will lead us to a better understanding of its nature. We are well on our way towards understanding the molecular structure and mechanisms involved in calcium permeability, and the coming decade promises to reveal numerous breakthroughs in our understanding of this channel.

摘要

二氢吡啶敏感性钙通道一直吸引着科研人员。每一项新发现都带来更多的复杂性。进一步阐明该通道各种亚型的分子结构和功能的工作,将使我们更好地理解其本质。我们在理解钙通透性所涉及的分子结构和机制方面已经取得了很大进展,未来十年有望在我们对该通道的理解上取得众多突破。

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