[主要组抗结核药物在体外的诱导凋亡作用]
[Apoptosis-inducing action of antituberculosis drugs of the main group in vitro].
作者信息
Vasilyeva O A, Serebryakova V A, Urazova O I, Novitsky V V, Kononova T E, Naslednikova I O
出版信息
Antibiot Khimioter. 2010;55(11-12):25-9.
PMID:21574422
Abstract
The influence of the main antituberculosis drugs (isoniazid, rifampicin, ethambutol) on in vitro apoptosis of peripheral blood lymphocytes from patients with pulmonary tuberculosis was researched. It was shown that all the investigated drugs induced apoptotic death of the lymphocytes in vitro, that could result in disturbance of antigen-specific response formation in pulmonary tuberculosis.
摘要
研究了主要抗结核药物（异烟肼、利福平、乙胺丁醇）对肺结核患者外周血淋巴细胞体外凋亡的影响。结果表明，所有研究药物均可在体外诱导淋巴细胞凋亡死亡，这可能导致肺结核患者抗原特异性反应形成障碍。
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