Grach A A
Tsitol Genet. 2011 Mar-Apr;45(2):69-81.
The review considers mechanisms of an alternative lengthening of telomeres (ALT) which possess the second after telomerase but not less important place in telomere length regulation. The general data about ALT are shown. An alternative lengthening of telomeres in normal and cancer cell lines are characterized. Special attention is given to the features of recombinational and retrotranspositional mechanisms of ALT.
本综述探讨了端粒替代延长（ALT）机制，该机制在端粒长度调节中仅次于端粒酶，具有同样重要的地位。文中展示了关于ALT的一般数据，对正常细胞系和癌细胞系中端粒的替代延长进行了特征描述，并特别关注了ALT的重组和逆转座机制特点。
