Wang Q, Mao L M, Han J S
Department of Physiology, Beijing Medical University, People's Republic of China.
Behav Brain Res. 1990 Mar 5;37(2):149-56. doi: 10.1016/0166-4328(90)90090-2.
Transections at two levels of the forebrain were undertaken in the rat to investigate the neural structures indispensable for the mediation of tail flick reflex suppression (TFRS) induced by low (2 Hz) and high (100 Hz) frequency electroacupuncture (EA) stimulation. Removal of the telencephalic structures did not affect TFRS produced by high frequency EA, although a mild and temporal attenuation was observed for low frequency EA-induced TFRS. Ablation of the whole forebrain (the telencephalon and diencephalon) resulted in a total abolishment of 2-Hz EA effect as measured 5, 24 and 72 h after surgery. In the meantime there was a moderate attenuation (-32.8%, P less than 0.05) of 100-Hz EA effect, which appeared 5 h after the operation and recovered after 24 h. The results indicate that (1) high frequency EA effect persisted in animals devoid of the whole forebrain structures; (2) an intact diencephalon is indispensable for the neural circuitry controlling low frequency EA-induced TFRS.
在大鼠的前脑两个水平进行横断手术，以研究对于介导低频（2赫兹）和高频（100赫兹）电针（EA）刺激诱导的甩尾反射抑制（TFRS）不可或缺的神经结构。去除端脑结构不影响高频EA产生的TFRS，尽管对于低频EA诱导的TFRS观察到轻度且短暂的减弱。切除整个前脑（端脑和间脑）导致在手术后5小时、24小时和72小时测量时，2赫兹EA效应完全消失。同时，100赫兹EA效应有中度减弱（-32.8%，P小于0.05），这在手术后5小时出现并在24小时后恢复。结果表明：（1）高频EA效应在缺乏整个前脑结构的动物中持续存在；（2）完整的间脑对于控制低频EA诱导的TFRS的神经回路是不可或缺的。
