Department Radiology, Medical University of South Carolina, Charleston, South Carolina, USA.
J Interferon Cytokine Res. 2011 Jul;31(7):527-31. doi: 10.1089/jir.2010.0151. Epub 2011 May 16.
Our primary objective in this study was to determine the differences in inflammatory profile between patients with high risk for obstructive sleep apnea (OSA) versus low risk in a patient population undergoing cardiac rehabilitation and to evaluate the effect of 4 weeks of rehabilitation on cytokine levels in the 2 groups. A total of 20 consecutive patients were screened using the Berlin questionnaire to determine high and low risk of OSA. Of the 20 total consecutive patients, 3 patients did not consent to participate and 1 did not get cytokine analysis. Of the remaining 16 patients (8 men and 8 women), 8 (50%) patients were found to have high risk for OSA as predicted by the Berlin questionnaire. Men predominated the high-risk group (75%). There was a trend of increased cytokine load in the high-risk group; however, it did not reach statistical significance except for monocyte chemoattractant protein-1 (P value=0.02). A significant reduction was noted in cytokine levels after 4 weeks of rehabilitation in the group with OSA, which was statistically significant (P value<0.5). The high-risk group patients had elevated cytokine levels, especially monocyte chemoattractant protein-1. Further, a significant reduction in cytokine levels was noted in the high-risk group after 4 weeks of rehabilitation.
我们这项研究的主要目的是确定在进行心脏康复的患者人群中，高危阻塞性睡眠呼吸暂停（OSA）患者与低危患者之间的炎症特征差异，并评估 4 周康复对 2 组细胞因子水平的影响。使用柏林问卷对 20 例连续患者进行了筛选，以确定 OSA 的高风险和低风险。在这 20 例连续患者中，有 3 例患者不同意参与，1 例未进行细胞因子分析。在其余 16 例患者（8 名男性和 8 名女性）中，有 8 例（50%）患者根据柏林问卷预测存在 OSA 高风险。高危组中男性居多（75%）。高危组细胞因子负荷呈增加趋势，但除单核细胞趋化蛋白-1（P 值=0.02）外，其他均未达到统计学意义。OSA 组在 4 周康复后细胞因子水平显著降低，具有统计学意义（P 值<0.5）。高危组患者细胞因子水平升高，尤其是单核细胞趋化蛋白-1。此外，高危组在 4 周康复后细胞因子水平显著降低。
