Kwon Woon Jung, Kim Hak Jin, Jeong Yeon Joo, Lee Chang Hun, Kim Kun-Il, Kim Yeong Dae, Lee Jong Hwa
Department of Diagnostic Radiology, Ulsan University Hospital, Ulsan University School of Medicine, Ulsan, Korea.
Exp Lung Res. 2011 Jun;37(5):310-7. doi: 10.3109/01902148.2011.566672. Epub 2011 May 16.
The objective of this study was to evaluate the effects on the histopathologic findings of directly injected lipiodol into lung and to identify the existence of remaining lipiodol in the lung according to the follow-up time. Forty rats were randomly assigned to 1 of 4 groups: group I (n = 10) served as the control group and received 0.2 mL of normal saline; groups II (n = 10), III (n = 10), and IV (n = 10) served as experimental groups and received 0.1-0.2 mL of lipiodol under fluoroscopy. At 3 hours (groups I and II), 24 hours (group III), and 1 week (group IV) after injection, the radiographic presence of lipiodol and histopathologic findings of each group were evaluated. Minimal acute lung injuries developed and the radio-opaque lipiodol nodule remained in group II. In group III, acute lung injuries were the most serious. However, acute injuries disappeared and foamy macrophages accumulated within the alveolar space in group IV. In this group, remaining lipiodol was also identified on radiograph. Directly injected lipiodol caused acute lung injury, which disappeared at 1 week along with the resolving process. On radiographs, directly injected lipiodol remained after 1 week. Lipiodol could be used as a safe and stable biomaterial for marking pulmonary nodules.
本研究的目的是评估直接向肺内注射碘油对组织病理学结果的影响，并根据随访时间确定肺内碘油残留情况。40只大鼠被随机分为4组中的1组：I组（n = 10）作为对照组，接受0.2 mL生理盐水；II组（n = 10）、III组（n = 10）和IV组（n = 10）作为实验组，在透视引导下接受0.1 - 0.2 mL碘油。注射后3小时（I组和II组）、24小时（III组）和1周（IV组），评估每组碘油的影像学表现和组织病理学结果。II组出现轻微急性肺损伤，不透射线的碘油结节仍存在。III组急性肺损伤最严重。然而，IV组急性损伤消失，肺泡腔内积聚泡沫状巨噬细胞。在该组中，影像学上也发现有残留碘油。直接注射碘油可导致急性肺损伤，1周时随着损伤的消退而消失。在影像学上，直接注射的碘油1周后仍有残留。碘油可作为标记肺结节的安全稳定生物材料。
