Mahmutovic Persson Irma, von Wachenfeldt Karin, Waterton John C, Olsson Lars E
Department of Translational Medicine, Medical Radiation Physics, Lund University, 20502 Malmö, Sweden.
Truly Labs, Medicon Village, 223 63 Lund, Sweden.
J Clin Med. 2020 Dec 30;10(1):107. doi: 10.3390/jcm10010107.
For drug-induced interstitial lung disease (DIILD) translational imaging biomarkers are needed to improve detection and management of lung injury and drug-toxicity. Literature was reviewed on animal models in which in vivo imaging was used to detect and assess lung lesions that resembled pathological changes found in DIILD, such as inflammation and fibrosis. A systematic search was carried out using three databases with key words "Animal models", "Imaging", "Lung disease", and "Drugs". A total of 5749 articles were found, and, based on inclusion criteria, 284 papers were selected for final data extraction, resulting in 182 out of the 284 papers, based on eligibility. Twelve different animal species occurred and nine various imaging modalities were used, with two-thirds of the studies being longitudinal. The inducing agents and exposure (dose and duration) differed from non-physiological to clinically relevant doses. The majority of studies reported other biomarkers and/or histological confirmation of the imaging results. Summary of radiotracers and examples of imaging biomarkers were summarized, and the types of animal models and the most used imaging modalities and applications are discussed in this review. Pathologies resembling DIILD, such as inflammation and fibrosis, were described in many papers, but only a few explicitly addressed drug-induced toxicity experiments.
对于药物性间质性肺病（DIILD），需要翻译成像生物标志物来改善肺损伤和药物毒性的检测与管理。本文回顾了相关文献，这些文献涉及利用体内成像检测和评估类似于DIILD中发现的病理变化（如炎症和纤维化）的肺部病变的动物模型。使用三个数据库，以“动物模型”“成像”“肺病”和“药物”为关键词进行了系统检索。共找到5749篇文章，根据纳入标准，选择了284篇论文进行最终数据提取，基于合格性，最终从这284篇论文中筛选出182篇。涉及12种不同动物物种，使用了9种不同的成像方式，三分之二的研究为纵向研究。诱导剂和暴露情况（剂量和持续时间）从非生理剂量到临床相关剂量不等。大多数研究报告了其他生物标志物和/或成像结果的组织学确认。本文总结了放射性示踪剂及成像生物标志物实例，并讨论了动物模型类型、最常用的成像方式及其应用。许多论文描述了类似于DIILD的病理情况，如炎症和纤维化，但只有少数明确涉及药物诱导毒性实验。
