Department of Biochemistry, Meram Faculty of Medicine, Selçuk University, Konya, Turkey.
Ren Fail. 2011;33(5):475-9. doi: 10.3109/0886022X.2011.577922.
We have investigated the effects of active and passive smoking on renal functions in terms of glomerular filtration rate, microalbuminuria, and β-2 microglobulin excretion.
The volunteers included in this study were classified into three groups as active smokers (n = 24), passive smokers (n = 20), and controls (n = 20). Blood and urine samples were collected from all groups. Serum glucose, urea, creatinine, and cotinine levels in the collected blood samples were measured. Also, microalbumin, β-2 microglobulin, and creatinine levels were measured in the collected urine samples.
Serum cotinine levels were found to be higher in both passive and active smokers when compared with controls ( p < 0.01), whereas urinary microalbumin and creatinine levels were significantly higher in active smokers ( p < 0.01). The urinary microalbumin/creatinine ratio was significantly increased in both active and passive smokers compared with controls.
The kidney and the glomerular functions may be affected even by passive smoking. In addition, increased microalbumin/creatinine ratio may be a sign of increased atherosclerosis risk in these persons.
我们研究了主动和被动吸烟对肾小球滤过率、微量白蛋白尿和β-2 微球蛋白排泄的肾功能的影响。
本研究的志愿者分为三组：主动吸烟者（n=24）、被动吸烟者（n=20）和对照组（n=20）。从所有组中采集血样和尿样。测量收集的血样中的血清葡萄糖、尿素、肌酐和可替宁水平。还测量了收集的尿样中的微量白蛋白、β-2 微球蛋白和肌酐水平。
与对照组相比，被动和主动吸烟者的血清可替宁水平均较高（p<0.01），而主动吸烟者的尿微量白蛋白和肌酐水平显著较高（p<0.01）。与对照组相比，主动和被动吸烟者的尿微量白蛋白/肌酐比值均显著升高。
即使是被动吸烟也可能影响肾脏和肾小球功能。此外，这些人微量白蛋白/肌酐比值的增加可能是动脉粥样硬化风险增加的迹象。
