Faculdade de Medicina de Jundiaí, Jundiaí, SP, Brazil.
Faculdade de Santa Bárbara D'Oeste, Jundiaí, SP, Brazil.
Einstein (Sao Paulo). 2022 Jul 25;20:eAO0011. doi: 10.31744/einstein_journal/2022AO0011. eCollection 2022.
To determine whether passive smoking causes morphological and structural changes in the arcuate arteries of rats exposed for 7 to 28 days.
Wistar rats aged eight weeks and weighing 260g on average were allocated to a Control or a Smoker Group. Groups were further divided into 4 groups containing 5 animals each. Morphological-functional analysis of the right kidneys was carried out after 7 and 28 days of exposure to the smoke of 40 cigarettes per day. Cigarettes were burned at set times using automated cigarette-burning equipment ("Smoking Machine" - SM-MC-01). At the end of each exposure period, the kidneys were dissected and submitted to histological processing for morphological and quantitative analysis.
Exposure to cigarette smoke for 7 days led to a decrease in inner vascular diameter. Decreased thickness of the vascular tunica media was observed after exposure for 28 days. Increased thickness of the tunica adventitia, increased total vascular wall thickness, increased total vascular diameter and qualitative increase in collagen deposition were observed. Vascular volume increased after 28 days of exposure.
Passive smoking has a negative impact on renal vasculature.
确定暴露于 7 至 28 天的被动吸烟是否会引起大鼠弓形动脉的形态和结构变化。
将 8 周龄、平均体重 260g 的 Wistar 大鼠分配到对照组或吸烟者组。每组进一步分为 4 组，每组 5 只动物。每天暴露于 40 支香烟的烟雾中 7 天和 28 天后，对右侧肾脏进行形态-功能分析。使用自动香烟燃烧设备（“吸烟机” - SM-MC-01）在规定时间燃烧香烟。在每次暴露结束时，解剖肾脏并进行组织学处理以进行形态和定量分析。
暴露于香烟烟雾 7 天导致内血管直径减小。暴露 28 天后，观察到血管中膜厚度减少。观察到外膜厚度增加、总血管壁厚度增加、总血管直径增加和胶原沉积定性增加。暴露 28 天后血管容积增加。
被动吸烟对肾脏血管有负面影响。
