Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.
Curr Protein Pept Sci. 2011 Jun;12(4):280-7. doi: 10.2174/138920311795906727.
Ghrelin is a stomach-derived peptide discovered as a ligand of the orphan G-protein coupled receptor. Ghrelin is now recognized as a major orexigenic neuropeptide. Immunohistochemical studies demonstrated that centrally administered ghrelin induced c-fos protein expression in many areas in the brain. Indeed, centrally administered ghrelin has various effects such as stimulating feeding, arousal, increasing gastric acid secretion, release of hormones from the pituitary, and inhibition of water intake. In particular, we recently showed that ghrelin was an antidipsogenic peptide with a simultaneous orexigenic effect. This may be of important, because most spontaneous daily water intake is temporally associated with feeding. Here, we summarise recent findings on the integration of central effects of ghrelin that regulate feeding, release hormones from the pituitary and inhibit fluid/water intake.
胃饥饿素是一种源自胃的肽类物质，被发现是孤儿 G 蛋白偶联受体的配体。胃饥饿素现在被认为是一种主要的食欲肽。免疫组织化学研究表明，中枢给予胃饥饿素可诱导大脑中许多区域的 c-fos 蛋白表达。事实上，中枢给予胃饥饿素具有多种作用，如刺激摄食、觉醒、增加胃酸分泌、垂体激素释放以及抑制水摄入。特别是，我们最近表明，胃饥饿素是一种具有同时摄食作用的抗利尿肽。这可能很重要，因为大多数自发的每日水摄入量与摄食在时间上是相关的。在这里，我们总结了最近关于调节摄食、垂体激素释放和抑制液体/水摄入的中枢胃饥饿素作用整合的发现。
