Kojima Masayasu, Hosoda Hiroshi, Kangawa Kenji
Molecular Genetics, Institute of Life Science, Kurume-University, Kurume, Fukuoka 839-0861, Japan.
Best Pract Res Clin Endocrinol Metab. 2004 Dec;18(4):517-30. doi: 10.1016/j.beem.2004.07.001.
Recent identification of novel appetite-regulating hormones has revealed the complex interactions of these humoral factors in the regulation of feeding behavior in mammals. One of these hormones, ghrelin, a natural ligand of the orphan receptor GHS-R, purified from stomach, is able to stimulate growth hormone release from pituitary cells. Ghrelin is a 28 amino acid peptide containing an n-octanoylated serine 3 residue that is essential for its activity. Ghrelin stimulates appetite by acting on the hypothalamic arcuate nucleus, the region known to control food intake. As an orexigenic peptide, ghrelin is therefore an endogenous regulator of feeding behavior from the peripheral tissues to the central nervous system.
最近对新型食欲调节激素的鉴定揭示了这些体液因子在调节哺乳动物摄食行为中的复杂相互作用。其中一种激素是胃饥饿素，它是孤儿受体GHS-R的天然配体，从胃中纯化得到，能够刺激垂体细胞释放生长激素。胃饥饿素是一种由28个氨基酸组成的肽，含有一个n-辛酰化的丝氨酸3残基，这对其活性至关重要。胃饥饿素通过作用于下丘脑弓状核来刺激食欲，下丘脑弓状核是已知控制食物摄入的区域。因此，作为一种促食欲肽，胃饥饿素是从外周组织到中枢神经系统的摄食行为的内源性调节因子。
