Sezione di Dermatologia Clinica, Allergologica e Venereologica, Dipartimento di Patologia Sistematica, Università di Napoli Federico II, 80131 Naples, Italy.
Br J Dermatol. 2011 Jun;164(6):1262-70. doi: 10.1111/j.1365-2133.2011.10271.x. Epub 2011 May 17.
Some of the cytokines that have effects on melanogenesis are also reported to be involved in psoriasis.
We therefore studied the relationship between psoriasis and melanocytic naevi. In particular, the aim of our study was to investigate the number of melanocytic naevi in patients with psoriasis vs. controls.
We performed a prospective case-control study, analysing 93 adult patients with psoriasis and 174 adult aged-matched controls. For each participant a questionnaire was completed to establish personal data, personal medical history, and personal and familial history of skin cancer and psoriasis. We analysed interleukin (IL)-1α, IL-6 and tumour necrosis factor (TNF)-α gene expression at the peripheral blood mononuclear cell level in patients with psoriasis and in controls.
In our study, patients with psoriasis presented a lower number of areas with naevi in comparison with controls (P < 0·0001). Nobody had ever had squamous cell carcinoma or melanoma in the psoriatic group; moreover, there was a significant difference in familial history of melanoma between the two groups (none in the psoriatic group vs. 8% in the control group; P < 0·05). IL-1α, IL-6 and TNF-α expression levels were higher in patients with psoriasis.
People with psoriasis had fewer melanocytic naevi. This suggests that the proinflammatory cytokine network in psoriasis skin might inhibit melanogenesis, melanocyte growth and/or progression to naevi.
一些对黑色素生成有影响的细胞因子也被报道与银屑病有关。
因此，我们研究了银屑病与黑素细胞痣之间的关系。我们特别研究了银屑病患者与对照组之间黑素细胞痣数量的关系。
我们进行了一项前瞻性病例对照研究，分析了 93 例成年银屑病患者和 174 例年龄匹配的成年对照组。每位参与者都填写了一份问卷，以确定个人数据、个人病史、个人和家族皮肤癌和银屑病病史。我们分析了银屑病患者和对照组外周血单个核细胞中白细胞介素（IL）-1α、IL-6 和肿瘤坏死因子（TNF）-α基因的表达。
在我们的研究中，与对照组相比，银屑病患者的痣面积较少（P<0·0001）。银屑病组中没有人曾患有鳞状细胞癌或黑色素瘤；此外，两组间黑色素瘤家族史存在显著差异（银屑病组无，对照组 8%；P<0·05）。IL-1α、IL-6 和 TNF-α的表达水平在银屑病患者中更高。
银屑病患者的黑素细胞痣较少。这表明银屑病皮肤中的促炎细胞因子网络可能抑制黑色素生成、黑素细胞生长和/或向痣的进展。
