Tang Bin, Bi Yang, Zheng Xuwei, Yang Yujie, Huang Xiaobing, Yang Kexin, Zhong Haixin, Han Ling, Lu Chuanjian, Chen Haiming
The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou 510120, China.
State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou 510120, China.
Pharmaceutics. 2024 Dec 12;16(12):1586. doi: 10.3390/pharmaceutics16121586.
Psoriasis is a chronic inflammatory polygenic disease with significant impacts on skin and joints, leading to substantial treatment challenges and healthcare costs. The quest for novel therapeutic avenues has recently highlighted extracellular vesicles (EVs) due to their potential as biomarkers and therapeutic agents in autoimmune diseases, including psoriasis. EVs are nano-sized, lipid membrane-bound particles secreted by cells that have emerged as promising tools for targeted drug delivery, owing to their unique structure. This review delves into how EVs, either as mediators of cell communication or via their cargo (such as miRNA), directly participate in the pathology of psoriasis, influencing processes such as immune regulation, cell proliferation, and differentiation. Furthermore, this review explores the innovative application of EVs in psoriasis treatment, both as direct therapeutic agents and as vehicles for drug delivery, offering a novel approach to overcoming the current treatment limitations.
银屑病是一种慢性炎症性多基因疾病，对皮肤和关节有重大影响，导致巨大的治疗挑战和医疗成本。由于细胞外囊泡（EVs）在包括银屑病在内的自身免疫性疾病中作为生物标志物和治疗剂的潜力，对新型治疗途径的探索最近突出了它们。EVs是细胞分泌的纳米大小、脂质膜结合的颗粒，由于其独特的结构，已成为有前景的靶向药物递送工具。本综述深入探讨了EVs如何作为细胞通讯介质或通过其货物（如miRNA）直接参与银屑病的病理过程，影响免疫调节、细胞增殖和分化等过程。此外，本综述探讨了EVs在银屑病治疗中的创新应用，既作为直接治疗剂，也作为药物递送载体，为克服当前治疗局限性提供了一种新方法。
