Underwood Martin
Warwick Medical School, University of Warwick, Coventry, UK.
BMJ Clin Evid. 2011 May 17;2011:1120.
Gout affects about 5% of men and 1% of women, with up to 80% of people experiencing a recurrent attack within 3 years.
We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of treatments for acute gout? What are the effects of treatments to prevent gout in people with prior acute episodes? We searched: Medline, Embase, The Cochrane Library, and other important databases up to September 2010 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
We found 16 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
In this systematic review, we present information relating to the effectiveness and safety of the following interventions: colchicine, corticosteroids, corticotropin (ACTH), non-steroidal anti-inflammatory drugs (NSAIDs), sulfinpyrazone, xanthine oxidase inhibitors, advice to lose weight, advice to reduce alcohol intake, and advice to reduce dietary intake of purines.
痛风影响约5%的男性和1%的女性，高达80%的患者会在3年内经历复发发作。
我们进行了一项系统综述，旨在回答以下临床问题：急性痛风治疗的效果如何？对既往有急性发作的患者，预防痛风的治疗效果如何？我们检索了：截至2010年9月的医学期刊数据库（Medline）、荷兰医学文摘数据库（Embase）、考克兰图书馆及其他重要数据库（《临床证据》综述会定期更新；请查看我们的网站获取本综述的最新版本）。我们纳入了来自美国食品药品监督管理局（FDA）和英国药品和医疗产品监管局（MHRA）等相关机构的危害警示。
我们找到了16项符合我们纳入标准的系统综述、随机对照试验或观察性研究。我们对干预措施证据的质量进行了GRADE评估。
在本系统综述中，我们提供了以下干预措施有效性和安全性的相关信息：秋水仙碱、皮质类固醇、促肾上腺皮质激素（ACTH）、非甾体抗炎药（NSAIDs）、磺吡酮、黄嘌呤氧化酶抑制剂、减重建议、减少酒精摄入建议以及减少膳食嘌呤摄入建议。
