Wan Ru-Gen, Chen De-Bao, Lou Yong-Gang, Wang Mao-Feng, Zhang Qiao-Hong, Jin Dan-Xia, Zhou Sun-Hong
Department of Clinical Laboratory, Dongyang Affiliated Hospital of Wenzhou Medical College (Dongyang People's Hospital), Dongyang, Zhejiang 322100, China.
Zhonghua Zhong Liu Za Zhi. 2011 Jan;33(1):47-9.
To evaluate the diagnostic value of serum angiopoietin-2 (Ang-2) level in pancreatic cancer patients.
Serum Ang-2 level was measured by enzyme-linked immunosorbent assays (ELISA) in samples from 116 patients with pancreatic cancer, 50 patients with chronic pancreatitis, and 50 normal control subjects.
The serum Ang-2 level in patients with pancreatic cancer [(1539.0 ± 449.3) ng/L] was significantly higher than those in patients with pancreatitis [(1044.6 ± 246.1) ng/L, P < 0.01] and normal control subjects [(1075.6 ± 228.2) ng/L, P < 0.01]. There was no significant difference of serum Ang-2 levels between patients with pancreatitis and normal controls. Pancreatic caner patients with lymph node metastasis had a significantly higher serum Ang-2 level [(1890.1 ± 354.9) ng/L] than those without metastasis [(1212.1 ± 224.2) ng/L, P < 0.01]. The area under ROC curve of serum Ang-2 level for diagnosis of pancreatic cancer was 0.819.
The serum Ang-2 level can be a useful indicator for diagnosis of pancreatic cancer.
评估血清血管生成素-2（Ang-2）水平在胰腺癌患者中的诊断价值。
采用酶联免疫吸附测定（ELISA）法检测116例胰腺癌患者、50例慢性胰腺炎患者及50例正常对照者样本中的血清Ang-2水平。
胰腺癌患者血清Ang-2水平[（1539.0±449.3）ng/L]显著高于胰腺炎患者[（1044.6±246.1）ng/L，P<0.01]和正常对照者[（1075.6±228.2）ng/L，P<0.01]。胰腺炎患者与正常对照者的血清Ang-2水平无显著差异。有淋巴结转移的胰腺癌患者血清Ang-2水平[（1890.1±354.9）ng/L]显著高于无转移患者[（1212.1±224.2）ng/L，P<0.01]。血清Ang-2水平诊断胰腺癌的ROC曲线下面积为0.819。
血清Ang-2水平可作为诊断胰腺癌的有用指标。
