在机械通气患者中通过体内微透析测量厄他培南进入肌肉的情况。
Penetration of ertapenem into muscle measured by in vivo microdialysis in mechanically ventilated patients.
机构信息
1Service d'anesthésie et de réanimation, Hôpital Nord, Assistance Publique—Hôpitaux de Marseille, Université de la Méditerranée, 13015 Marseille, France.
出版信息
Antimicrob Agents Chemother. 2011 Jul;55(7):3573-5. doi: 10.1128/AAC.00180-11. Epub 2011 May 16.
Abstract
Ertapenem at 1 g once daily has been suggested to be underdosed in intensive care unit (ICU) patients to attain optimal concentrations in target tissues. Therefore, our study aimed to assess the kinetics of ertapenem in plasma and skeletal muscle in ICU patients using microdialysis. Average muscle free-ertapenem concentrations were above the MIC values of targeted pathogens. In a few patients, the concentrations were below the MIC values. The clinical efficiency of ertapenem at 1 g once daily should be evaluated in a large population of ICU patients.
摘要
厄他培南 1 克每日一次在重症监护病房（ICU）患者中可能剂量不足，无法在靶组织中达到最佳浓度。因此，我们的研究旨在使用微透析评估 ICU 患者体内血浆和骨骼肌中厄他培南的药代动力学。平均肌肉游离厄他培南浓度高于目标病原体的 MIC 值。在少数患者中，浓度低于 MIC 值。厄他培南 1 克每日一次的临床疗效应在大量 ICU 患者中进行评估。
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