Miner Thomas J, Cohen Jonah, Charpentier Kevin, McPhillips Jane, Marvell Lauren, Cioffi William G
Department of Surgery, The Alpert Medical School of Brown University, Rhode Island Hospital, 593 Eddy St, APC 4, Providence, RI 02903, USA.
Arch Surg. 2011 May;146(5):517-22. doi: 10.1001/archsurg.2011.92.
To examine the outcomes of patients managed with the palliative triangle method and to evaluate factors associated with effective patient selection.
Patients receiving a procedure to palliate symptoms of advanced cancer were identified prospectively from all surgical palliative care consultations and observed for at least 90 days or until death.
Academic surgical oncology service.
A total of 227 patients symptomatic from advanced incurable cancer.
The palliative triangle technique was used to select patients for palliative operations.
Symptom resolution, overall survival, and complications.
We evaluated 227 patients from July 1, 2004, through June 30, 2009. Reasons cited for not selecting 121 patients (53.3%) for a palliative procedure were low symptom severity (23.9%), decision for nonoperative palliation (19.0%), patient preference (19.8%), concerns about complications (15.7%), and other (21.6%). A palliative operation was performed in 106 patients (46.7%) for complaints of gastrointestinal obstruction (35.8%), local control of tumor-related symptoms (25.5%), jaundice (10.4%), and other (28.3%). Of these 106 patients, 5 required procedures for recurrent symptoms and 6 for additional symptoms; of the 121 patients originally not selected, 12 required procedures for progressive symptoms, for a total of 129 procedures. Patient-reported symptom resolution or improvement was noted in 117 of 129 procedures (90.7%). Palliative procedures were associated with 30-day postoperative morbidity (20.1%) and mortality (3.9%). Median survival was 212 days.
Palliative operations performed in these carefully selected patients were associated with significantly better symptom resolution and fewer postoperative complications compared with previously published results.
研究采用姑息三角法治疗的患者的治疗效果,并评估与有效患者选择相关的因素。
从所有外科姑息治疗会诊中前瞻性地识别出接受缓解晚期癌症症状手术的患者,并观察至少90天或直至死亡。
学术性外科肿瘤服务机构。
共有227例晚期不治之症有症状的患者。
采用姑息三角技术选择进行姑息手术的患者。
症状缓解情况、总生存期和并发症。
我们评估了2004年7月1日至2009年6月30日期间的227例患者。未选择121例患者(53.3%)进行姑息手术的原因包括症状严重程度低(23.9%)、决定采用非手术姑息治疗(19.0%)、患者偏好(19.8%)、对并发症的担忧(15.7%)以及其他原因(21.6%)。106例患者(46.7%)因胃肠道梗阻(35.8%)、局部控制肿瘤相关症状(25.5%)、黄疸(10.4%)及其他原因(28.3%)进行了姑息手术。在这106例患者中,5例因症状复发需要再次手术,6例因出现其他症状需要再次手术;在最初未被选择的121例患者中,12例因症状进展需要手术,总共进行了129例手术。129例手术中有117例(90.7%)患者报告症状得到缓解或改善。姑息手术与30天术后发病率(20.1%)和死亡率(3.9%)相关。中位生存期为212天。
与先前发表的结果相比,在这些经过精心挑选的患者中进行的姑息手术,症状缓解情况明显更好,术后并发症更少。