Ackroyd-Stolarz S A, MacKinnon N J, Murphy N, Gillespie E, Zed P J
Department of Emergency Medicine, Dalhousie University, Halifax, NS.
J Popul Ther Clin Pharmacol. 2011;18(2):e250-6. Epub 2011 May 2.
Poison centres are an underutilized source of information on adverse events related to medications, including therapeutic errors and adverse drug reactions.
To demonstrate the feasibility of using a poison centres' electronic data to identify and describe adverse events related to medications.
This one-year, retrospective cross-sectional pilot study was conducted at one Canadian Poison Centre. All records from the IWK Regional Poison Centre database in Nova Scotia between November 1, 2007 and October 31, 2008 for unintentional exposures were abstracted for a descriptive data analysis.
An issue related to use of a medication was the main reason for 1,525 (32.5%) of 4,697 eligible calls. Of the 1,525 calls, 970 (63.6%) were coded as 'unintentional-general.' There were 470 (30.8%) calls for unintentional therapeutic errors and 61 (4.0%) for adverse drug reactions. The majority of calls involving medications were judged to have resulted in minimal or no toxic effect (78.4%). However, 3.3% of calls involving adverse drug reactions resulted in admission to a critical care unit (n=2). Approximately 1% of calls involving unintentional therapeutic errors resulted in admission to hospital (n=6).
Calls to poison centres provide a potentially valuable source of information on adverse events related to medications that are likely not reported elsewhere. Establishment of a mechanism to routinely share information from all Canadian poison centres with relevant national drug safety programs (e.g., MedEffect™ Canada) will provide a supplementary source of information and contribute to building capacity for detection of sentinel events and pharmacosurveillance.
中毒控制中心是有关药物相关不良事件（包括治疗失误和药物不良反应）信息的未充分利用来源。
证明利用中毒控制中心的电子数据识别和描述药物相关不良事件的可行性。
这项为期一年的回顾性横断面试点研究在一家加拿大中毒控制中心开展。提取了新斯科舍省IWK地区中毒控制中心数据库2007年11月1日至2008年10月31日期间所有非故意暴露记录进行描述性数据分析。
药物使用相关问题是4697例符合条件呼叫中1525例（32.5%）的主要原因。在这1525例呼叫中，970例（63.6%）被编码为“非故意-一般”。有470例（30.8%）为非故意治疗失误呼叫，61例（4.0%）为药物不良反应呼叫。大多数涉及药物的呼叫被判定导致最小毒性作用或无毒性作用（78.4%）。然而，3.3%的药物不良反应呼叫导致入住重症监护病房（n = 2）。约1%的非故意治疗失误呼叫导致住院（n = 6）。
拨打中毒控制中心的电话提供了有关药物相关不良事件的潜在宝贵信息来源，而这些信息可能在其他地方未被报告。建立一种机制，定期将所有加拿大中毒控制中心的信息与相关国家药物安全项目（如加拿大MedEffect™）共享，将提供补充信息来源，并有助于增强对哨点事件的检测能力和药物监测能力。
