Department of Cardiology, College of Medicine, Seoul St Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
Circ J. 2011;75(7):1685-90. doi: 10.1253/circj.cj-10-1248. Epub 2011 May 17.
The roles of soluble and endogenous secretory receptors for advanced glycation endproducts (sRAGE and esRAGE, respectively) in plaque vulnerability are unknown in patients with acute myocardial infarction (AMI).
We enrolled 54 patients with AMI (27 patients had type 2 diabetes mellitus [DM]) who had undergone primary percutaneous coronary intervention, and 54 controls who were matched for age, gender and the presence of DM. Plasma levels of s/esRAGE and matrix metalloproteinase (MMP)-9 were measured at the time of coronary angiography. There were no significant differences in the baseline characteristics of the AMI and control groups, except for the C-reactive protein levels (CRP: 14.1 ± 14.2 mg/L vs. 3.7 ± 5.2 mg/L, P < 0.001). The plasma levels of MMP-9 (28.6 ± 21.4 vs. 14.3 ± 8.5 ng/ml P < 0.001) and sRAGE (0.61 ± 0.28 vs. 0.41 ± 0.17 ng/ml, P < 0.001) were higher in the AMI group than in the controls. In multivariate logistic regression analysis, the plasma levels of MMP-9 and sRAGE above the median (odds ratio [OR], 2.39; 95% confidence interval [CI], 1.02-5.58; P = 0.044; OR, 2.47; 95%CI, 1.05-5.80; P = 0.039, respectively) were independent predictors of AMI, as well as being a current smoker (OR, 2.98; 95%CI, 1.18-7.55; P = 0.021) and CRP ≥ 3.0 mg/L (OR, 3.08; 95%CI, 1.25-7.59; P = 0.015).
An elevated plasma level of sRAGE might be independently associated with plaque vulnerability, as well as MMP-9, in patients with AMI.
可溶性和内源性晚期糖基化终产物受体（sRAGE 和 esRAGE）在急性心肌梗死（AMI）患者斑块易损性中的作用尚不清楚。
我们纳入了 54 例接受经皮冠状动脉介入治疗的 AMI 患者（27 例患有 2 型糖尿病[DM]），以及 54 例匹配年龄、性别和 DM 存在的对照组。在冠状动脉造影时测量血浆可溶性/内源性 RAGE（s/esRAGE）和基质金属蛋白酶（MMP）-9 水平。AMI 组和对照组的基线特征除 C 反应蛋白水平（CRP：14.1±14.2 mg/L 比 3.7±5.2 mg/L，P<0.001）外，无显著差异。与对照组相比，AMI 组 MMP-9（28.6±21.4 比 14.3±8.5 ng/ml，P<0.001）和 sRAGE（0.61±0.28 比 0.41±0.17 ng/ml，P<0.001）的血浆水平更高。在多元逻辑回归分析中，中位数以上的 MMP-9 和 sRAGE 血浆水平（比值比[OR]，2.39；95%置信区间[CI]，1.02-5.58；P=0.044；OR，2.47；95%CI，1.05-5.80；P=0.039）是 AMI 的独立预测因子，此外还包括当前吸烟者（OR，2.98；95%CI，1.18-7.55；P=0.021）和 CRP≥3.0 mg/L（OR，3.08；95%CI，1.25-7.59；P=0.015）。
在 AMI 患者中，sRAGE 血浆水平升高可能与 MMP-9 一样，与斑块易损性独立相关。
