转化生长因子β1 +869T/C基因多态性与原发性高血压：一项涉及2708名中国人群参与者的荟萃分析。
Transforming growth factor β1 +869T/C gene polymorphism and essential hypertension: a meta-analysis involving 2708 participants in the Chinese population.
作者信息
Yan-Yan Li
机构信息
Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University, China.
出版信息
Intern Med. 2011;50(10):1089-92. doi: 10.2169/internalmedicine.50.4967. Epub 2011 May 1.
BACKGROUND
The transforming growth factor β1 (TGFB1) +869T/C gene polymorphism has been suggested to be linked to susceptibility to essential hypertension (EH).
OBJECTIVE AND METHODS
To investigate the relationship between TGFB1 +869T/C gene polymorphism and EH, 5 separate studies with 2,708 subjects in the Chinese population on the relation between TGFB1 +869T/C gene polymorphism and EH were analyzed by meta-analysis. The random effect model was selected to calculate the pooled odds ratio (ORs) and its corresponding 95% confidence interval (95%).
RESULTS
There was a significant association between TGFB1 +869T/C gene polymorphism and EH. The pooled OR for CC/TC+TT genotype was 2.50 (95% CI: 1.46-4.28, P (heterogeneity) <0.0001, p=0.0008). The pooled OR for the frequency of C allele was 1.43 (95% CI:1.18-1.73, P (heterogeneity) =0.02, p=0.0002).
CONCLUSION
The current meta-analysis suggested that C allele and CC genotype of TGFB1 +869T/C gene polymorphism might be related to the increased risk of EH in the Chinese population.
背景
转化生长因子β1（TGFB1）+869T/C基因多态性被认为与原发性高血压（EH）易感性相关。
目的与方法
为研究TGFB1 +869T/C基因多态性与EH的关系，采用Meta分析方法对中国人群中5项关于TGFB1 +869T/C基因多态性与EH关系的独立研究（共2708例受试者）进行分析。选择随机效应模型计算合并比值比（OR）及其相应的95%置信区间（95%CI）。
结果
TGFB1 +869T/C基因多态性与EH之间存在显著关联。CC/TC+TT基因型的合并OR为2.50（95%CI：1.46 - 4.28，P（异质性）<0.0001，p = 0.0008）。C等位基因频率的合并OR为1.43（95%CI：1.18 - 1.73，P（异质性）=0.02，p = 0.0002）。
结论
当前的Meta分析表明，TGFB1 +869T/C基因多态性的C等位基因和CC基因型可能与中国人群中EH风险增加有关。
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