伴有抗利尿激素分泌不当综合征的食管小细胞癌
Esophageal small-cell carcinoma with syndrome of inappropriate secretion of antidiuretic hormone.
作者信息
Ando Takayuki, Hosokawa Ayumu, Yamawaki Hidemoto, Hasumoto Yuushi, Kajiura Shinya, Itaya Yuko, Ueda Akira, Suzuki Nobuhiro, Nishikawa Jun, Fujinami Haruka, Miyazaki Takako, Ogawa Kouhei, Sugiyama Toshiro
机构信息
Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, Japan.
出版信息
Intern Med. 2011;50(10):1099-103. doi: 10.2169/internalmedicine.50.4694. Epub 2011 May 1.
Small-cell carcinoma (SCC) of the esophagus is rare, and its clinical characteristics remain poorly understood. A 54-year-old man was given a diagnosis of esophageal SCC and underwent esophagectomy. Four months after surgery, he was admitted to our hospital because of rapidly developing hyponatremia. Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH) due to extensive recurrence of SCC was diagnosed. Combined chemotherapy with irinotecan and cisplatin has dramatically reduced metastatic tumors, and it was concomitantly effective for SIADH. This case demonstrates that esophageal SCC could induce SIADH as a paraneoplastic syndrome and that the above combined chemotherapy was feasible and effective.
食管小细胞癌（SCC）较为罕见，其临床特征仍鲜为人知。一名54岁男性被诊断为食管SCC并接受了食管切除术。术后四个月，他因迅速发展的低钠血症入住我院。诊断为SCC广泛复发导致的抗利尿激素分泌不当综合征（SIADH）。伊立替康和顺铂联合化疗显著缩小了转移瘤，并且对SIADH也有疗效。该病例表明食管SCC可诱发SIADH作为副肿瘤综合征，且上述联合化疗可行且有效。
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