Doi Hikaru, Arimura Kimiyoshi, Ohyagi Yasumasa, Kira Jun-Ichi
Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Japan.
Intern Med. 2011;50(10):1113-5. doi: 10.2169/internalmedicine.50.4998. Epub 2011 May 1.
A 25-year-old woman complained of numbness of the extremities, following muscle rigidity and tenderness. The presence of anti-voltage-gated potassium channel antibody led to the diagnosis of Isaacs' syndrome. Twenty-seven months after the first symptom, she developed a pricking pain sensation in the lateral left foot, and then gradually developed a purple skin lesion resembling frostbite. The lesion completely disappeared 2 days later. An incidental episode occurred at the same site 8 months later. Frostbite-like skin lesions may be a rare autonomic manifestation in Isaacs' syndrome.
一名25岁女性在出现肌肉僵硬和压痛后，诉说四肢麻木。抗电压门控钾通道抗体的存在导致了艾萨克斯综合征的诊断。在出现首发症状27个月后，她左足外侧出现刺痛感，随后逐渐出现类似冻伤的紫色皮肤病变。该病变在2天后完全消失。8个月后在同一部位发生了一次偶然事件。类似冻伤的皮肤病变可能是艾萨克斯综合征中一种罕见的自主神经表现。
