Institute of Biomedical Research, Georg-Speyer-Haus, Frankfurt am Main, Germany.
J Innate Immun. 2011;3(4):344-54. doi: 10.1159/000327014. Epub 2011 May 11.
Human natural killer (NK) cells recognize and efficiently eliminate MHC class I low or negative malignant targets and virally infected host cells, without requirement for prior sensitization. However, viruses and various tumor cells display elaborate adaptations to evade and overcome immunosurveillance. The current review focuses on escape mechanisms of viruses and malignantly transformed 'stressed' cells to evade from NK cell cytotoxicity. A general overview of recent clinical studies using allogeneic donor NK cells is given, summarizing first data about a possible benefit for patients suffering from high-risk leukemia and solid tumors. Finally, the review discusses the future perspectives and hypotheses aiming to improve therapeutic NK cell strategies against tumor immune escape mechanisms.
人类自然杀伤 (NK) 细胞识别并有效消除 MHC Ⅰ类低表达或阴性的恶性靶标和病毒感染的宿主细胞，而无需预先致敏。然而，病毒和各种肿瘤细胞表现出精心的适应机制来逃避和克服免疫监视。本综述重点关注病毒和恶性转化“应激”细胞逃避 NK 细胞细胞毒性的逃逸机制。概述了使用同种异体供体 NK 细胞的最新临床研究，总结了有关高危白血病和实体瘤患者可能受益的初步数据。最后，该综述讨论了旨在改善针对肿瘤免疫逃逸机制的治疗性 NK 细胞策略的未来展望和假设。
