Jensen J B, Garfinkel B D
Division of Child Psychiatry, University of Minnesota Medical School, Minneapolis 55455.
J Am Acad Child Adolesc Psychiatry. 1990 Mar;29(2):295-301. doi: 10.1097/00004583-199003000-00021.
The growth hormone response to stimulation with oral clonidine and L-dopa was measured in 14 boys with major depressive disorder (MDD) and 15 normal boys. The six MDD boys who were prepubertal or in early puberty were significantly lower than the 10 normal subjects of this age in peak growth hormone response following clonidine administration (p = 0.029) and area under the curve for clonidine (p = 0.030) and L-dopa (p = 0.028). The eight later puberty MDD boys did not differ from the five later puberty normal boys on any measures.
对14名患有重度抑郁症（MDD）的男孩和15名正常男孩测量了口服可乐定和左旋多巴刺激后的生长激素反应。6名青春期前或青春期早期的MDD男孩在服用可乐定后的生长激素峰值反应（p = 0.029）、可乐定曲线下面积（p = 0.030）和左旋多巴曲线下面积（p = 0.028）方面显著低于该年龄的10名正常受试者。8名青春期后期的MDD男孩在任何测量指标上与5名青春期后期的正常男孩均无差异。
