Jensen J B, Garfinkel B D
University of Minnesota Hospital and Clinic, Minneapolis.
Neurol Clin. 1988 Feb;6(1):111-29.
This article summarizes the existing neuroendocrine literature and reports the growth hormone response to stimulation with L-dopa and clonidine in male children and adolescents with attention deficit hyperactivity disorder. Because growth hormone secretion is regulated by monoamine neurotransmitters, hyposecretion of growth hormone may reflect generalized changes in the neurochemical substrate of this disorder. With refinement, these neuroendocrine challenge tests may become unique biologic markers in identifying attention deficit hyperactivity disorder in children and adolescents.
本文总结了现有的神经内分泌文献，并报告了患有注意力缺陷多动障碍的男性儿童和青少年对左旋多巴和可乐定刺激的生长激素反应。由于生长激素分泌受单胺类神经递质调节，生长激素分泌不足可能反映了该疾病神经化学底物的普遍变化。随着技术的完善，这些神经内分泌激发试验可能会成为识别儿童和青少年注意力缺陷多动障碍的独特生物学标志物。
