Clinical Nutrition Unit, Internal Medicine IV, Department of Internal Medicine and Clinical Oncology, University of Bari, School of Medicine, Policlinico, Bari, Italy.
Obes Facts. 2011;4(2):159-63. doi: 10.1159/000327893. Epub 2011 Apr 15.
The study aim was to compare C3 levels with the common carotid artery intima-media thickness (CCAIMT) in subjects of both genders, with a wide range of BMI, independently of age, gender, and abdominal obesity.
140 euthyroid, mainly overweight/obese subjects (age 18-30 years) were examined. BMI, waist circumference, blood pressure, fasting insulin, glucose, lipids, C3 and C-reactive protein serum concentrations, and insulin resistance degree (estimated by homeostasis model assessment for insulin resistance (HOMAIR)) were measured.
CCA-IMT was positively (p < 0.001) correlated with BMI, waist circumference, systolic and diastolic blood pressures, HOMAIR, and insulin, CRP, and C3 serum levels. The multiple linear regression analysis showed that only male gender and waist circumference maintained an independent relation with the CCA-IMT.
This study suggests that central fat accumulation and male gender independently increase the thickness of the arterial wall, whereas inflammation and inflammatory markers do not have an independent effect on this parameter.
本研究旨在比较不同性别、BMI 广泛范围内人群的 C3 水平与颈总动脉内膜中层厚度（CCAIMT）的相关性，且该相关性不依赖于年龄、性别和腹型肥胖。
共纳入 140 例甲状腺功能正常、主要超重/肥胖的受试者（年龄 18-30 岁）。检测 BMI、腰围、血压、空腹胰岛素、血糖、血脂、血清 C3 和 C-反应蛋白浓度以及胰岛素抵抗程度（通过稳态模型评估的胰岛素抵抗指数（HOMAIR）进行评估）。
CCA-IMT 与 BMI、腰围、收缩压和舒张压、HOMAIR、胰岛素、CRP 和 C3 血清水平呈正相关（p<0.001）。多元线性回归分析显示，仅男性和腰围与 CCA-IMT 独立相关。
本研究表明，中心性脂肪堆积和男性性别独立增加了动脉壁的厚度，而炎症和炎症标志物对该参数没有独立影响。
