De Pergola Giovanni, Tartagni Massimo, Bartolomeo Nicola, Bruno Irene, Masiello Michele, Caccavo Domenico, Bavaro Serena, Silvestris Franco
Clinical Nutrition Unit, Medical Oncology, Department of Biomedical Sciences and Human Oncology, Section of Clinical Oncology, University of Bari, School of Medicine, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy.
Endocr Metab Immune Disord Drug Targets. 2013 Dec;13(4):301-5. doi: 10.2174/1871530314666140116111542.
A group of 608 apparently healthy patients, 136 men and 472 women, either overweight or obese, aged 18-69 years, were examined. BMI, waist circumference, fasting blood glucose (FBG), insulin, and complement 3 (C3) serum levels were measured; the homeostasis model assessment (HOMAIR) was used to evaluate insulin resistance; and physical activity was quantified by a questionnaire.
HOMAIR showed a positive correlation with BMI (r: 0.478, p < 0.001), waist circumference (r: 0.487, p < 0.001), and C3 (r: 0.445, p < 0.001). Moreover, it was significantly associated with gender (F Fisher = 22.12, p < 0.001), and the mean HOMAIR levels were significantly different among the three groups of physical activity, with the lowest level of insulin resistance at the highest level of physical activity (F=7,31, p < 0.001). A multiple regression analysis was carried out with HOMAIR as the dependent variable and gender, age, BMI, waist circumference, C3 and the level of physical activity as independent variables (fitted model: F = 41.24, P<0.001, R2 = 0.328). HOMAIR maintained an independent association with C3 (β = 0.678, P<0.001), sex (β = 0.189, P<0.001), BMI (β = 0.637, P<0.01), and age (β = -0.004, P<0.05).
This study of a cohort of overweight and obese subjects has shown that insulin resistance (dependent variable) is positively associated with C3 serum levels, independently of age, gender, anthropometric parameters and physical activity, suggesting that higher C3 serum levels may directly increase insulin resistance in obesity.
对一组608名年龄在18至69岁之间、明显健康的超重或肥胖患者进行了检查，其中男性136名，女性472名。测量了体重指数（BMI）、腰围、空腹血糖（FBG）、胰岛素和补体3（C3）血清水平；采用稳态模型评估（HOMAIR）来评估胰岛素抵抗；并通过问卷调查对身体活动进行量化。
HOMAIR与BMI（r：0.478，p<0.001）、腰围（r：0.487，p<0.001）和C3（r：0.445，p<0.001）呈正相关。此外，它与性别显著相关（F Fisher=22.12，p<0.001），并且在三组身体活动中，HOMAIR的平均水平存在显著差异，身体活动水平最高时胰岛素抵抗水平最低（F=7.31，p<0.001）。以HOMAIR作为因变量，性别、年龄、BMI、腰围、C3和身体活动水平作为自变量进行多元回归分析（拟合模型：F = 41.24，P<0.001，R2 = 0.328）。HOMAIR与C3（β = 0.678，P<0.001）、性别（β = 0.189，P<0.001）、BMI（β = 0.637，P<0.01）和年龄（β = -0.004，P<0.05）保持独立关联。
这项对超重和肥胖受试者队列的研究表明，胰岛素抵抗（因变量）与C3血清水平呈正相关，独立于年龄、性别、人体测量参数和身体活动，提示较高的C3血清水平可能直接增加肥胖中的胰岛素抵抗。
